4.4 Article

DOXORUBICIN CAUSES DIAPHRAGM WEAKNESS IN MURINE MODELS OF CANCER CHEMOTHERAPY

Journal

MUSCLE & NERVE
Volume 43, Issue 1, Pages 94-102

Publisher

WILEY
DOI: 10.1002/mus.21809

Keywords

chemotherapy; inflammation; oxidative stress; respiratory muscle; weakness

Funding

  1. American Heart Association
  2. National Institutes of Health [T32-HL-086341, AR055974, AG032009]
  3. NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL086341] Funding Source: NIH RePORTER
  4. NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR055974] Funding Source: NIH RePORTER
  5. NATIONAL INSTITUTE ON AGING [R03AG032009] Funding Source: NIH RePORTER

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Doxorubicin is a chemotherapeutic agent prescribed for a variety of tumors. While undergoing treatment, patients exhibit frequent symptoms that suggest respiratory muscle weakness. Cancer patients can receive doxorubicin chemotherapy through either intravenous (IV) or intraperitoneal (IP) injections. We hypothesized that respiratory muscle function would be depressed in a murine model of chemotherapy. We tested this hypothesis by treating C57BL/6 mice with a clinical dose of doxorubicin (20 mg/kg) via IV or IP injection. Three days later we measured contractile properties of muscle fiber bundles isolated from the diaphragm. Doxorubicin consistently depressed diaphragm force with both methods of administration (P < 0.01). Doxorubicin IP exaggerated the depression in diaphragm force and stimulated tissue inflammation and muscle fiber injury. These results suggest that clinically relevant doses of doxorubicin cause respiratory muscle weakness and that the loss of function depends, in part, on the route of administration. Muscle Nerve 43: 94-102, 2011

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