4.4 Article

PRIMARY AMYLOIDOSIS PRESENTING AS UPPER LIMB MULTIPLE MONONEUROPATHIES

Journal

MUSCLE & NERVE
Volume 41, Issue 5, Pages 710-715

Publisher

WILEY
DOI: 10.1002/mus.21561

Keywords

amyloidosis; amyloid neuropathy; mononeuritis multiplex; necrotizing vasculitis; nerve biopsy

Funding

  1. National Institutes of Neurological Disorders and Stroke [NS36797]

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Peripheral neuropathy in primary (AL) amyloidosis is usually lower-limb predominant, length-dependent, symmetrical, and affects small (pain and autonomic) fibers, as much or more than large fibers. We report a patient with step-wise progressive, multiple upper limb mononeuropathies that were due to nerve biopsy-proven primary amyloidosis (lambda light chain), with no systemic or autonomic features. Recognition that light chain amyloidosis may be the cause of a multiple mononeuropathy pattern adds to the differential diagnosis of this clinical phenotype. Muscle Nerve 41: 710-715, 2010

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