Journal
MUSCLE & NERVE
Volume 42, Issue 4, Pages 600-603Publisher
WILEY
DOI: 10.1002/mus.21763
Keywords
animal models; cardiomyopathy; Duchenne muscular dystrophy; ECG; gender; hemodynamics; mdx
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Funding
- National Institutes of Health [AR-49419]
- Muscular Dystrophy Association
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL091883] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR049419] Funding Source: NIH RePORTER
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Aged mdx mice represent an important model for studying Duchenne cardiomyopathy. Herein we compared the cardiac phenotypes of 22-month-old male and female mdx mice. Surprisingly, only females displayed the characteristic cardiac dilation on pressure-volume loop analysis. Female mdx mice also exhibited lower contractility, larger Q waves, and higher ratios of heart weight to body weight. Our results reveal significant gender disparity in mdx cardiac function. Gender should be considered when using the mdx model for the study of Duchenne cardiomyopathy. Muscle Nerve 42: 600-603, 2010
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