Journal
MUSCLE & NERVE
Volume 41, Issue 4, Pages 441-443Publisher
WILEY
DOI: 10.1002/mus.21602
Keywords
ALS; Renshaw cell; recurrent inhibition; corticospinal; motoneuron
Categories
Ask authors/readers for more resources
In this article the role of Renshaw cell involvement in experimental amyotrophic lateral sclerosis (ALS) is discussed, with an emphasis on the anatomy, physiology, and possible role in motor control of Renshaw cells. These cells are located in lamina VII of the spinal cord, are excited by motor axon collaterals, and inhibit homonymous and synergistic motoneurons in a negative-feedback fashion (recurrent inhibition). Early dysfunction and/or loss of Renshaw cells has been suggested to occur in experimental ALS, and the hypothesis has been put forward that this may be the event that makes motoneurons more susceptible to glutamatergic toxicity in ALS. However, Renshaw cell properties and connectivity in particular, the lack of recurrent inhibition in the more distal muscles of the limbs where, on the contrary, initial wasting is prominent in human ALS make it unlikely that impairment of Renshaw cells is a general feature of the human form of the disease. Muscle Nerve 41: 441-443, 2010
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available