Journal
SENSORS
Volume 15, Issue 8, Pages 19912-19924Publisher
MDPI
DOI: 10.3390/s150819912
Keywords
dopamine; tyrosinase; enzyme; nanosensor; DNA; dendrimer
Funding
- Defense Advanced Research Projects Agency (DARPA) Young Investigator Award [D12AP00246]
- National Science Foundation Graduate Research Fellowship [DGE-0946746]
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Dopamine is widely innervated throughout the brain and critical for many cognitive and motor functions. Imbalances or loss in dopamine transmission underlie various psychiatric disorders and degenerative diseases. Research involving cellular studies and disease states would benefit from a tool for measuring dopamine transmission. Here we show a Quadruplex Integrated DNA (QuID) nanosensor platform for selective and dynamic detection of dopamine. This nanosensor exploits DNA technology and enzyme recognition systems to optically image dopamine levels. The DNA quadruplex architecture is designed to be compatible in physically constrained environments (110 nm) with high flexibility, homogeneity, and a lower detection limit of 110 mu M.
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