Journal
MUSCLE & NERVE
Volume 40, Issue 5, Pages 801-808Publisher
WILEY
DOI: 10.1002/mus.21398
Keywords
acetylcholine receptor antibody; complement 3; myasthenia gravis; quantitative myasthenia gravis scores
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Funding
- National Natural Science Foundation of China [30570641, 30870841]
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Acute exacerbation of generalized myasthenia gravis (GMG) can cause swallowing impairment, respiratory failure, or death. It is important to identify immunological factors that might be regarded reliably as an index of the patient's clinical condition, response to treatment, and measure of certain immune aberrations of MG. In this study we investigated correlations between complement component C3, acetylcholine receptor antibody (AChRab) titer, and clinical severity of GMG. AChRab titer and C3 concentration were determined by radioimmunoassay and nephelometry, respectively. The clinical severity of GMG was assessed by the quantitative MG score (QMGS) according to Besinger and colleagues. Our findings indicate that the C3 level correlates with clinical severity of AChRab-positive GMG. Muscle Nerve 40:801-808, 2009
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