Journal
MUSCLE & NERVE
Volume 41, Issue 2, Pages 202-207Publisher
WILEY
DOI: 10.1002/mus.21480
Keywords
acute inflammatory demyelinating polyneuropathy; chronic inflammatory demyelinating polyneuropathy; clinical predictors; electrophysiology; sural sparing
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Funding
- Talecris Biotherapeutics
- Bourse McLaughlin du Doyen de l'Universite Laval
- Royal College of Physician and Surgeon Traineeship Grant
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Up to 16% of chronic inflammatory demyelinating polyneuropathy (CIDP) patients may present acutely. We performed a retrospective chart review on 30 acute inflammatory demyelinating polyneuropathy (AIDIP) and 15 acute-onset CIDIP (A-CIDP) patients looking for any clinical or electrophysiological parameters that might differentiate AIDP from acutely presenting CIDP. A-CIDP patients were significantly more likely to have prominent sensory signs. They were significantly less likely to have autonomic nervous system involvement, facial weakness, a preceding infectious illness, or need for mechanical ventilation. With regard to electrophysiological features, neither sural-sparing pattern, sensory ratio >1, nor the presence of A-waves was different between the two groups. This study suggests that patients presenting acutely with a demyelinating polyneuropathy and the aforementioned clinical features should be closely monitored as they may be more likely to have CIDIP at follow-up. Muscle Nerve 41: 202-207, 2010
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