Journal
MUSCLE & NERVE
Volume 38, Issue 1, Pages 861-866Publisher
WILEY
DOI: 10.1002/mus.21006
Keywords
plantaris; functional overload; satellite cell; muscle regulatory factor
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Funding
- NIAMS NIH HHS [R03 AR049855, R03 AR 049855, R03 AR049855-03] Funding Source: Medline
- NINDS NIH HHS [P01 NS016333, NS 16333] Funding Source: Medline
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Paired box (Pax) proteins 3 and 7 are key determinants for embryonic skeletal muscle development by initiating myogenic regulatory factor (MRF) gene expression. We show that Pax3 and 7 participate in adult skeletal muscle plasticity during the initial responses to chronic overload (<= 7 days) and appear to coordinate MyoD expression, a member of the MRF family of genes. Pax3 and 7 mRNA were higher than control within 12 h after initiation of overload, preceded the increase in MyoD mRNA on day 1, and peaked on day 2. On days 3 and 7, Pax7 mRNA remained higher than control, suggesting that satellite cell self-renewal was occurring. Pax3 and 7 and MyoD protein levels were higher than control on days 2 and 3. These data indicate that Pax3 and 7 coordinate the recapitulation of developmental-like regulatory mechanisms in response to growth-inducing stimuli in adult skeletal muscle, presumably through activation of satellite cells.
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