Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 19, Issue 14, Pages 1887-1895Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458513489757
Keywords
Clinically isolated syndrome; optical coherence tomography; retinal nerve fiber layer; retinal ganglion cell layer
Categories
Funding
- German Research Foundation [DFG Exc 257]
- German Federal Ministry of Economics and Technology [BMWi ZIM KF2286101FO9]
- Walter-and-Ilse-Rose-Stiftung
- Eugene Devic European Network (E-rare/EU-FP7)
- German Ministry for Education and Research (BMBF, 'German Competence Network Multiple Sclerosis', KKNMS-BMBF)
Ask authors/readers for more resources
Background: Axonal and neuronal damage are widely accepted as key events in the disease course of multiple sclerosis. However, it has been unclear to date at which stage in disease evolution neurodegeneration begins and whether neuronal damage can occur even in the absence of acute inflammatory attacks. Objective: To characterize inner retinal layer changes in patients with clinically isolated syndrome (CIS). Method: 45 patients with CIS and age- and sex-matched healthy controls were investigated using spectral domain optical coherence tomography. Patients' eyes were stratified into the following categories according to history of optic neuritis (ON): eyes with clinically-diagnosed ON (CIS-ON), eyes with suspected subclinical ON (CIS-SON) as indicated by a visual evoked potential latency of >115ms and eyes unaffected by ON (CIS-NON). Results: CIS-NON eyes showed significant reduction of ganglion cell- and inner plexiform layer and a topography similar to that of CIS-ON eyes. Seven eyes were characterized as CIS-SON and likewise showed significant retinal layer thinning. The most pronounced thinning was present in CIS-ON eyes. Conclusion: Our findings indicate that retinal pathology does occur already in CIS. Intraretinal layer segmentation may be an easily applicable, non-invasive method for early detection of retinal pathology in patients unaffected by ON.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available