Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 19, Issue 13, Pages 1802-1809Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458513488232
Keywords
Biomarkers; cerebrospinal fluid; control groups; study design
Categories
Funding
- Czech Ministry of Health [NT 13183]
- Research Project Charles University in Prague [PRVOUK 34/LF3]
- Kristian Gerhard Jebsen Foundation
- Ministry of Education and Science, Republic of Serbia [175031]
- Dutch Foundation of MS Research
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The choice of appropriate control group(s) is critical in cerebrospinal fluid (CSF) biomarker research in multiple sclerosis (MS). There is a lack of definitions and nomenclature of different control groups and a rationalized application of different control groups. We here propose consensus definitions and nomenclature for the following groups: healthy controls (HCs), spinal anesthesia subjects (SASs), inflammatory neurological disease controls (INDCs), peripheral inflammatory neurological disease controls (PINDCs), non-inflammatory neurological controls (NINDCs), symptomatic controls (SCs). Furthermore, we discuss the application of these control groups in specific study designs, such as for diagnostic biomarker studies, prognostic biomarker studies and therapeutic response studies. Application of these uniform definitions will lead to better comparability of biomarker studies and optimal use of available resources. This will lead to improved quality of CSF biomarker research in MS and related disorders.
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