Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 20, Issue 8, Pages 1066-1073Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458513515084
Keywords
MRI; multiple sclerosis; relapsing-remitting; rotating frame relaxation; inversion-prepared MT; adiabatic pulses
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Funding
- National Institutes of Health (NIH) [P41RR08079, P41EB015894, S10 RR023730, S10 RR027290, KL2 RR033182, R01NS061866, R21NS059813]
- National Institutes of Health (NIH) an Academic Health Center (AHC) seed grant from the University of Minnesota
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Background: Diffuse abnormalities are known to occur within the brain tissue of multiple sclerosis (MS) patients that is normal appearing on T1-weighted and T2-weighted magnetic resonance images. Objectives: With the goal of exploring the sensitivity of novel MRI parameters to detect such abnormalities, we implemented an inversion-prepared magnetization transfer (MT) protocol and adiabatic T1 rho and T2 rho rotating frame relaxation methods. Methods: Nine relapsing remitting MS patients and seven healthy controls were recruited. Relaxation parameters were measured in a single slice just above the lateral ventricles and approximately parallel to the AC-PC line. Results: The MT ratio of regions encompassing the normal-appearing white matter (NAWM) was different in MS patients as compared with controls (p = 0.043); however, the T1 measured during off-resonance irradiation (T1 sat) was substantially more sensitive than the MT ratio for detecting differences between groups (p = 0.0006). Adiabatic T I p was significantly prolonged in the NAWM of MS patents as compared to controls (by 6%, p = 0.026), while no differences were found among groups for T2 rho. No differences among groups were observed in the cortical gray matter for any relaxation parameter. Conclusions: The results suggest degenerative processes occurring in the NAWM of MS, likely not accompanied by significant abnormalities in iron content.
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