Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 20, Issue 8, Pages 1131-1134Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458513513969
Keywords
MRI; multiple sclerosis; cognition; atrophy
Categories
Funding
- Dutch MS Research Foundation [08-648]
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Previous studies showed that advanced neuroimaging measures (functional MRI, diffusion tensor imaging) could distinguish multiple sclerosis (MS) patients with and without cognitive impairment. Are these measures indeed better indicators for cognitive impairment or subjective cognitive complaints than conventional MRI? Fifty MS patients and 29 controls were investigated. Regression analysis, including socio-demographic data, disease characteristics, psychological measures, and (advanced) neuroimaging, showed that worse cognitive performance was associated with male sex, lower education, and lower gray matter volume. Subjective cognitive complaints were associated with fatigue and less hippocampal atrophy. Advanced MRI measures did not add to the predictive power of our model.
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