Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 18, Issue 9, Pages 1337-1339Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458512439438
Keywords
natalizumab; multiple sclerosis; magnetic resonance imaging
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Funding
- Biogen Idec Inc.
- Sanofi-Aventis
- Biogen Idec
- Bayer Schering
- Merck Serono
- Novartis
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The recommended natalizumab dosage is 300 mg every 4 weeks. We evaluated radiological activity at various times from the last natalizumab infusion by examining 386 magnetic resonance imaging (MRI) scans from 166 natalizumab-treated patients with relapsing-remitting MS. Of 113 scans performed > 4 weeks after last natalizumab infusion, 26 were active (i.e. had >= 1 contrast-enhancing lesions). Risk of radiological activity increased by 1.34 fold for each week of delay with respect to the recommended 4-week dosing interval, compared with schedule-adherent patients (p < 0.0001). Our data suggest that an increased MRI activity >= 7 weeks from the last infusion of natalizumab should be considered in cases of therapy discontinuation.
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