Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 18, Issue -, Pages 7-15Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458512441566
Keywords
multiple sclerosis; MS; cost-of-illness; costs; economic burden; utilities; fatigue; activities of daily living; France; Germany; Italy; Spain; United Kingdom; UK
Categories
Funding
- Novartis Pharmaceuticals
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Background: Multiple sclerosis (MS) is a common cause of neurological disability in young adults. The TRIBUNE study provides a detailed exploration of costs in relation to relapses and disease severity, and assesses the quality of life impact on MS patients in terms of utilities, fatigue and activities of daily living (ADL). Methods: Patients in five European countries (France, Germany, Italy, Spain and the United Kingdom) completed a self-administered web-based questionnaire capturing information on demographics, disease characteristics and severity (EDSS), co-morbidities, relapses, resource consumption, utilities, fatigue, and activities of daily living. Results: In total, 1261 MS patients completed the questionnaire. More than half of the patients (68%) had the relapsing-remitting form of the disease; 87% of the sample reported receiving MS treatments. Costs were higher with advancing disease severity; for mild patients (EDSS score 3) the costs ranged between Euro13,534 and Euro22,461 across countries; for moderate (EDSS score 4 - 6.5) between Euro28,524 and Euro43,948; for severe (EDSS 7) between Euro39,592 and Euro65,395. Relapses were also associated with increasing costs; the difference in the cost per patient per year for relapsing-remitting patients with EDSS score 5 that did experience at least one relapse during the past 12 months and those who did not ranged between Euro3321 and Euro9430. The quality of life of patients decreased with disease progression and existence of relapses. Conclusion: The TRIBUNE study provides an important update on the economic burden of MS in an era of more widespread use of disease-modifying therapies. It explores the cost of MS linked to relapses and disease severity, and examines the impact of MS on additional health outcomes beyond utilities such as ADL and fatigue.
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