Journal
MULTIPLE SCLEROSIS
Volume 16, Issue 10, Pages 1248-1251Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458510376956
Keywords
EDSS; MSRV; multiple sclerosis; prognosis; retrovirus; secondary progressive
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Funding
- Regione Autonoma Sardegna (RAS)
- Fondazione Italiana Sclerosi Multipla (FISM, Genoa) [2002/R/51, 2003/R/21]
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Retrovirus-like particles containing the multiple sclerosis-associated retrovirus RNA, significantly found in the cerebrospinal fluid of patients with multiple sclerosis, have been preliminarily associated with a short-term poor clinical and radiological prognosis of the disease. We asked whether these prognostic indications are still measurable after a long-term clinical evaluation (10 years). Our 10-year blind observational study confirms that the presence of multiple sclerosis-associated retrovirus in the cerebrospinal fluid of early multiple sclerosis patients is associated with a significantly greater rate of relapse-unrelated unremitting disability and secondary progression of the disease.
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