Journal
MULTIPLE SCLEROSIS JOURNAL
Volume 16, Issue 9, Pages 1148-1151Publisher
SAGE PUBLICATIONS LTD
DOI: 10.1177/1352458510375440
Keywords
brain atrophy; cognitive intervention; executive functioning; multiple sclerosis
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Funding
- Sanofi-Aventis Inc.
- Bayer HealthCare Inc.
- Merck-Serono Inc.
- Villigst foundation (study foundation of the protestant church)
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We evaluated a rehabilitation programme for executive deficits in multiple sclerosis patients by comparing outcome scores of a cognitive intervention group (CIG; n = 11) with those of a placebo group (n = 14) and an untreated group (n = 15). Executive functioning and verbal learning improved significantly more in the CIG. The treatment effect on verbal learning was still present at 1-year follow-up. Baseline brain atrophy, quantified by the brain parenchymal fraction, was associated with treatment effects for one aspect of executive functioning. Consequently, cognitive intervention may be beneficial and baseline brain atrophy has some predictive value in determining treatment outcome for executive functioning.
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