Journal
AQUATIC TOXICOLOGY
Volume 164, Issue -, Pages 145-154Publisher
ELSEVIER
DOI: 10.1016/j.aquatox.2015.05.005
Keywords
Tetrabromobisphenol A; Aquatic organisms; pH; Acute toxicity; Oxidative stress
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Funding
- National Natural Science Foundation of China [41071319, 21377051]
- Major Science and Technology Program for Water Pollution Control and Treatment of China [2012ZX07506-001]
- Scientific Research Foundation of Graduate School of Nanjing University [2013CL08]
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Tetrabromobisphenol A (TBBPA) is a well-known brominated flame retardant. It has been detected in the environment and shows high acute toxicity to different organisms at high concentrations. In this work, the effects of pH and dimethyl sulfoxide (DMSO) on the acute toxicity of TBBPA to Daphnia magna and Limnodrilus hoffmeisteri were tested, and the oxidative stress induced by TBBPA in livers of Carassius aural-us was assessed using four biomarkers. The integrated biomarker response (IBR) was applied to assess the overall antioxidant status in fish livers. Moreover, fish tissues (gills and livers) were also studied histologically. The results showed that low pH and DMSO enhanced the toxicity of TBBPA. Furthermore, changes in the activity of antioxidant enzymes and glutathione level suggested that TBBPA generates oxidative stress in fish livers. The IBR index revealed that fish exposed to 3 mg/L TBBPA experienced more serious oxidative stress than exposed to acidic or alkaline conditions. The histopathological analysis revealed lesions caused by TBBPA. This study provides valuable toxicological information of TBBPA and will facilitate a deeper understanding on its potential toxicity in realistic aquatic environments. (C) 2015 Elsevier B.V. All rights reserved.
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