Journal
MUCOSAL IMMUNOLOGY
Volume 8, Issue 3, Pages 545-558Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2014.87
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Funding
- NordForsk Nordic PPP PhD program
- Novo Nordisk A/S
- Swedish Medical Research Council
- IngaBritt and Arne Lundbergs Foundation
- Swedish National Health Service
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Mucosal tissues contain large numbers of memory CD4(+) T cells that, through T-cell receptor-dependent interactions with antigen-presenting cells, are believed to have a key role in barrier defense and maintenance of tissue integrity. Here we identify a major subset of memory CD4(+) Tcells at barrier surfaces that coexpress interleukin-18 receptor alpha (IL-18R alpha) and death receptor-3 (DR3), and display innate lymphocyte functionality. The cytokines IL-15 or the DR3 ligand tumor necrosis factor (TNF)-like cytokine 1A(TL1a) inducedmemory IL-18R alpha(+)DR3(+)CD4(+) Tcells to produce interferon-gamma, TNF-alpha, IL-6, IL-5, IL-13, granulocyte-macrophage colony-stimulating factor (GM-CSF), and IL-22 in the presence of IL-12/ IL-18. TL1a synergized with IL-15 to enhance this response, while suppressing IL-15-induced IL-10 production. TL1a- and IL-15-mediated cytokine induction required the presence of IL-18, whereas induction of IL-5, IL-13, GM-CSF, and IL-22 was IL-12 independent. IL-18R alpha(+)DR3(+)CD4(+) T cells with similar functionality were present in human skin, nasal polyps, and, in particular, the intestine, where in chronic inflammation they localized with IL-18-producing cells in lymphoid aggregates. Collectively, these results suggest that human memory IL-18R alpha(+)DR3(+)CD4(+) T cells may contribute to antigen-independent innate responses at barrier surfaces.
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