Journal
MUCOSAL IMMUNOLOGY
Volume 5, Issue 1, Pages 7-18Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2011.55
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Funding
- Crohn's and Colitis Fellowship of America
- National Health and Medical Research Council of Australia
- National Institute of Health of the United States of America
- Australian Research Council
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Chronic obstructive pulmonary disease (COPD) and inflammatory bowel diseases (IBDs) are chronic inflammatory diseases of mucosal tissues that effect the respiratory and gastrointestinal tracts, respectively. They share many similarities in epidemiological and clinical characteristics, as well as in inflammatory pathologies. Importantly, both conditions are accompanied by systemic comorbidities that are largely overlooked in both basic and clinical research. Therefore, consideration of these complications may maximize the efficacy of prevention and treatment approaches. Here, we examine both the intestinal involvement in COPD and the pulmonary manifestations of IBD. We also review the evidence for inflammatory organ cross-talk that may drive these associations, and discuss the current frontiers of research into these issues.
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