Journal
MUCOSAL IMMUNOLOGY
Volume 4, Issue 5, Pages 496-502Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2011.22
Keywords
-
Categories
Funding
- Fonden til Laegevidenskabens Fremme (the AP Moller Foundation)
- Family Erichsen Memorial Foundation
- Axel Muusfeldts Foundation
- Foundation of Aase and Ejnar Danielsen
Ask authors/readers for more resources
Interleukin 33 (IL-33) is a recently discovered cytokine member of the IL-1 superfamily that is widely expressed in fixed tissue cells, including endothelial and epithelial cells. IL-33 induces helper T cells, mast cells, eosinophils, and basophils to produce type-2 cytokines through binding to the ST2/IL-1 receptor accessory protein complex. Recent studies have shown IL-33 to be upregulated in intestinal parasite infection and in epithelial cells and myofibroblasts in ulcerative colitis (UC). The findings point to a role for IL-33 in directing the T(H)2-type immune responses in these types of mucosal inflammation. As the IL-33/ST2 receptor axis can be manipulated by various blocking antibodies, this could be a potential therapeutic target in the future treatment of UC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available