Journal
MUCOSAL IMMUNOLOGY
Volume 3, Issue 1, Pages 69-80Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2009.109
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Funding
- National Institutes of Health (Bethesda, MD) [NIAID/NIH U19 AI070503-01, NHLBI/NIH P01 HL70831-01, NHLBI R01HL080412]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL070831, R01HL080412] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U19AI070503] Funding Source: NIH RePORTER
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Rhinovirus (RV) infections trigger asthma exacerbations. Genome-wide expression analysis of RV1A-infected primary bronchial epithelial cells from normal and asthmatic donors was performed to determine whether asthma is associated with a unique pattern of RV-induced gene expression. Virus replication rates were similar in cells from normal and asthmatic donors. Overall, RV downregulated 975 and upregulated 69 genes. Comparisons of transcriptional profiles generated from microarrays and confirmed by quantitative reverse transcription PCR and cluster analysis showed some up-and downregulated genes in asthma cells involved in immune responses (IL1B, IL1F9, IL24, and IFI44) and airway remodeling (LOXL2, MMP10, FN1). Notably, most of the asthma-related differences in RV-infected cells were also present in the cells before infection. These findings suggest that differences in RV-induced gene expression profiles of cells from normal and mild asthmatic subjects could affect the acute inflammatory response to RV, and subsequent airway repair and remodeling.
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