Journal
MUCOSAL IMMUNOLOGY
Volume 3, Issue 1, Pages 40-48Publisher
SPRINGERNATURE
DOI: 10.1038/mi.2009.115
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Funding
- Swedish Medical Research Council
- Crafoordska
- Richard and Ruth Julins
- Osterlund
- Nanna Svartz and Kocks Foundations
- Royal Physiographic Society in Lund
- Swedish Foundation for Strategic Research
- SWEGENE
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Intestinal-derived chemokines have a central role in orchestrating immune cell influx into the normal and inflamed intestine. Here, we identify the chemokine CCL6 as one of the most abundant chemokines constitutively expressed by both murine small intestinal and colonic epithelial cells. CCL6 protein localized to crypt epithelial cells, was detected in the gut lumen and reached high concentrations at the mucosal surface. Its expression was further enhanced in the small intestine following in vivo administration of LPS or after stimulation of the small intestinal epithelial cell line, mIC(c12), with IFN gamma, IL-4 or TNF alpha. Recombinant-and intestinal-derived CCL6 bound to a subset of the intestinal microflora and displayed antibacterial activity. Finally, the human homologs to CCL6, CCL14 and CCL15 were also constitutively expressed at high levels in human intestinal epithelium, were further enhanced in inflammatory bowel disease and displayed similar antibacterial activity. These findings identify a novel role for constitutively expressed, epithelial-derived chemokines as antimicrobial peptides in the intestinal mucosa.
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