Journal
MUCOSAL IMMUNOLOGY
Volume 3, Issue 2, Pages 138-147Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2009.134
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Funding
- NHLBI NIH HHS [P01 HL098067] Funding Source: Medline
- NIAMS NIH HHS [R01 AR056113, R01 AR055695] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL098067] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR055695, R01AR056113] Funding Source: NIH RePORTER
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Exposure to allergens first occurs at body surfaces in direct contact with the environment such as the skin, airways, and gastrointestinal tract, and compelling evidence suggests that allergic inflammatory responses are profoundly influenced by the products of epithelial cells located at these sites. One such product is thymic stromal lymphopoietin (TSLP), which is capable of affecting multiple cell lineages involved in allergic reactions. In this review we discuss recent work that has provided insight into the role TSLP plays in both aberrant and protective allergic inflammatory responses, as well as regulation, associations with disease, sources, and functions of this important cytokine.
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