Journal
MUCOSAL IMMUNOLOGY
Volume 2, Issue 6, Pages 468-471Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/mi.2009.107
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Immunoglobulin (Ig) A is the most abundant antibody isotype in mucosal secretions. In this study we summarize recent advances in our understanding of the compartments and mechanisms of intestinal IgA synthesis. We discuss the pathways leading to the generation of IgA(+) B cells in follicular and extra-follicular structures, by T-cell-dependent and T-cell-independent mechanisms.
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