Journal
AQUATIC TOXICOLOGY
Volume 161, Issue -, Pages 231-241Publisher
ELSEVIER
DOI: 10.1016/j.aquatox.2015.02.007
Keywords
Crassostrea angulata; Kinetics; Metallothionein; Glutathione; Enzymatic activity; Integrated biomarker response
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Funding
- Agencia Espanola de Cooperacion Internacional (AECID)
- Junta de Andalucia of activities of the research group RNM 306 of the Research Plan of Andalusia
- project CSIC-FCT [2007PT0040]
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The kinetics of cadmium (Cd) accumulation in the gills and digestive gland of Crassotrea angulata at three concentrations of cadmium (0.088 mu M, 0.44 mu M and 2.22 mu M) was monitored for 28 days. The relationship between accumulation and toxicity was studied using metallothionein-like protein (MTLP) concentration and reduced glutathione levels (GSH) as biochemical endpoints. The activity of enzymes which form part of the antioxidant defense system, in particular glutathione reductase (GR), total glutathione peroxidase (GPx), superoxide dismutase (SOD) and catalase (CAT), as enzymatic endpoints, was also assessed. A first order kinetic model demonstrated that the accumulation process does not take place linearly, as the Cd concentration in gills and digestive gland tended toward a stationary state. Metallothionein-like protein is clearly induced by Cd accumulation; however, at high Cd concentrations the detoxification mechanism of this protein is affected. High Cd concentrations (2.22 mu M) lead to a decrease in GSH levels, and also inhibit antioxidant enzyme activities, demonstrating the adverse effect of this metal on the antioxidant balance system. (C) 2015 Elsevier B.V. All rights reserved.
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