Journal
SEMINARS IN THROMBOSIS AND HEMOSTASIS
Volume 41, Issue 7, Pages 728-736Publisher
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0035-1564043
Keywords
neutrophils; tissue factor; autoimmune diseases; immuno-thrombosis; thrombo-inflammation
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Funding
- Italian Ministry of Health [RF-2001-02352291]
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The transition from the classic role of neutrophils as the first line of defense of the immune system to that of physiological regulators of intravascular thrombosis took nearly three decades to emerge. This transition needed time to unravel the complex links between the mechanisms that regulate hemostasis and inflammation and the innate immune response, multicellular and multifactorial processes that interact with each other. The present review is focused on the expression of tissue factor by neutrophils, a critical event in their inflammatory and thrombotic function.
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