Journal
MOVEMENT DISORDERS
Volume 29, Issue 8, Pages 1053-1057Publisher
WILEY
DOI: 10.1002/mds.25841
Keywords
Parkinson's disease; alpha-synuclein; gene; survival; association
Categories
Funding
- Italian Telethon Foundation [GTB07001]
- Fondazione Grigioni per il Morbo di Parkinson
- National Institutes of Health [R01 ES10751, P50 NS072187]
- Medical Research Council UK
- Midlands Neuroscience Teaching and Research Fund
- Queen Elizabeth Hospital Birmingham Charity
- Interuniversity Attraction Poles program of the Belgian Science Policy Office
- Foundation for Alzheimer Research
- Belgian Parkinson Foundation
- Methusalem Excellence Program of the Flemish Government
- Research Foundation Flanders
- Agency for Innovation by Science and Technology Flanders
- Special Research Fund of the University of Antwerp, Antwerp, Belgium
- Mayo Clinic Florida Research Committee CR program
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Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society
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