Journal
MOVEMENT DISORDERS
Volume 28, Issue 8, Pages 1133-1137Publisher
WILEY-BLACKWELL
DOI: 10.1002/mds.25405
Keywords
Parkinson's disease; vitamin D; accidental falls
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Funding
- Parkinson's Study Group
- Pakrinson's Disease Foundation Advancing Parkinson's Treatments Innovations Grant
- Oregon Clinical and Translation Research Institute (OCTRI) from the National Center for Research Resources (NCRR), a component of the National Institutes of Health (NIH) [UL1 RR024140]
- NIH Roadmap for Medical Research
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Background: Balance problems and falls are a major source of morbidity and mortality in patients with Parkinson's disease. Vitamin D supplementation reduces falls and sway in neurologically intact elderly fallers, but effects in Parkinson's disease are not established. Methods: To study this relationship and select outcome measures for a vitamin D intervention study, balance function and vitamin D concentration were quantified in a series of Parkinson's patients in a cross-sectional, observational study. Participants underwent a battery of 5 balance tests. Results: Serum vitamin D concentrations were correlated inversely with Parkinson's severity, as measured by the motor Unified Parkinson's Disease Rating Scale. Among the balance measures, vitamin D concentrations were correlated with automatic posture responses to backwards translation, specifically with response strength and stance weight asymmetry. Conclusions: These findings support the hypothesis that vitamin D plays a role in balance among patients with Parkinson's disease and identify specific outcome measures for detecting effects of vitamin D upon balance. (c) 2013 Movement Disorder Society
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