Journal
MOVEMENT DISORDERS
Volume 27, Issue 5, Pages 597-607Publisher
WILEY
DOI: 10.1002/mds.24921
Keywords
a-synuclein; autonomic nervous system; enteric nervous system; incidental Lewy body disease; Lewy body disease; neurodegeneration; neuron-to-neuron transmission; Parkinson's disease; Lewy neurites; bodies; PARS; premotor Parkinson's disease; sporadic Parkinson's disease; spinal cord; superior cervical ganglion
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Funding
- German Research Council (Deutsche Forschungsgemeinschaft, DFG)
- Michael J. Fox Foundation for Parkinson's Disease Research (New York, NY)
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The foremost motor manifestations of Parkinson's disease are resting tremor, cogwheel rigidity, hypokinesia/bradykinesia, and postural instability. Epidemiological and clinical data reveal that a wide variety of additional complaints (nonmotor symptoms), also considerably impar patients' quality of life parallel to the chronic-progressive neurodegenerative disorder. This article reviews the neuropathology and anatomy of Lewy pathology-related neurodegeneration in relation to selected nonmotro and prodromal dysfunctions. (C) 2012 Movement Disorder Society
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