Journal
MOVEMENT DISORDERS
Volume 27, Issue 12, Pages 1574-1577Publisher
WILEY
DOI: 10.1002/mds.25174
Keywords
MSA; atypical parkinsonism; follow-up; progression; sample-size estimate
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Funding
- French Health Ministry
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Background: Multiple system atrophy (MSA) has considerable effect on health-related quality of life (Hr-QoL). The aim of this study was to prospectively evaluate Hr-QoL by using the MSA health-related Quality of Life (MSA-QoL) scale. Methods: Evaluation of 100 patients at baseline and after a mean follow-up of 11.5 months was performed. Assessment was made of potential associations with established markers of disease progression. Calculation was performed of sample-size estimates for various effect sizes. Results: MSA-QoL scale scores were less responsive to change than Unified MSA Rating Scale (UMSARS) scores. Responsiveness was largely improved and reasonable sample-size estimates were obtained when limiting the analysis to items with significant change over time. Conclusions: The UMSARS remains the gold standard for disease-modifying/neuroprotection trials. An MSA-QoL Change Scale, based on the most responsive items, may become a valuable tool. (c) 2012 Movement Disorder Society
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