Journal
MOVEMENT DISORDERS
Volume 26, Issue 8, Pages 1386-1397Publisher
WILEY-BLACKWELL
DOI: 10.1002/mds.23737
Keywords
Parkinson's disease; leucine-rich repeat kinase 2; genetic mouse models; G2019S; kinase inhibitors
Categories
Funding
- NIH/NINDS [NS060809-01, NS072359-01]
- Michael J. Fox Foundation for Parkinson's Research
Ask authors/readers for more resources
Dominantly inherited mutations in leucine-rich repeat kinase 2 are the most common cause of familial Parkinson's disease. Understanding leucine-rich repeat kinase 2 biology and pathophysiology is central to the elucidation of Parkinson's disease etiology and development of disease intervention. Recently, a number of genetic mouse models of leucine-rich repeat kinase 2 have been reported utilizing different genetic approaches. Some similarities in Parkinson's disease-related pathology emerge in these genetic models despite lack of substantial neuropathology and clinical syndromes of Parkinson's disease. The systematic characterization of these models has begun to shed light on leucine-rich repeat kinase 2 biology and pathophysiology and is expected to offer the identification and validation of drug targets. In this review, we summarize the progress of genetic leucine-rich repeat kinase 2 mouse models and discuss their utility in understanding much needed knowledge regarding early-stage (presymptomatic) disease progression, identifying drug targets, and exploring the potential to aid compound screening focused on inhibitors of kinase activity of leucine-rich repeat kinase 2. (C) 2011 Movement Disorder Society
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available