Journal
MOVEMENT DISORDERS
Volume 26, Issue 12, Pages 2283-2286Publisher
WILEY-BLACKWELL
DOI: 10.1002/mds.23934
Keywords
Parkinson's disease; alpha-synuclein; GATA transcription factors; biomarker; genome-wide association study
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Funding
- NIH [R01 NS064155, R21 NS060227, K24 NS060991]
- Harvard NeuroDiscovery Center
- Michael J. Fox Foundation
- M.E.M.O. Hoffman Foundation
- RJG Foundation
- Neurologix, Inc.
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Background: Mutations in the alpha-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies. Methods: We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study. Results: The common minor allele of rs2736990 was associated with elevated disease susceptibility (odds ratio, 1.40; P = .0032). Conclusions: This result increases confidence in the notion that in many clinically well-characterized patients, genetic variation in SNCA contributes to sporadic disease. (C) 2011 Movement Disorder Society
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