Journal
MOVEMENT DISORDERS
Volume 26, Issue 9, Pages 1729-1732Publisher
WILEY
DOI: 10.1002/mds.23693
Keywords
Parkinson disease; transcription factor; paired-like homodomain transcription factor 3; susceptibility
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Funding
- Central South University, Changsha, China
- Baylor College of Medicine, Houston, Texas
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Background: Paired-like homodomain transcription factor 3 has been found to be important for the differentiation and survival of midbrain dopaminergic neurons. Methods: To determine whether genetic variation in the coding region of the paired-like homodomain transcription factor 3 gene plays a role in Parkinson's disease, genetic analysis was performed in 112 patients with Parkinson's disease. Results: We did not identify any mutations except rs2281983, but when we extended the analysis of rs2281983 and 2 intron variants (rs4919621 and rs3758549) in 336 patients with Parkinson's disease and 244 controls, we found that rs2281983 and rs4919621 appeared to confer susceptibility to Parkinson's disease, especially in early-onset Parkinson's disease and familial Parkinson's disease. (C) 2011 Movement Disorder Society
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