Journal
MOVEMENT DISORDERS
Volume 25, Issue 11, Pages 1701-1707Publisher
WILEY
DOI: 10.1002/mds.23197
Keywords
alpha-Synuclein; calcium binding protein; olfactory bulb; olfactory deficit; Parkinson's disease; transgenic mice; tyrosine hydroxylase
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Funding
- Autonomous Government of Castilla-La Mancha-FEDER [PI-2006/15, GCS-2006 E/03, PCC08-0064]
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Impaired olfaction is an early symptom of Parkinson's disease. The underlying neuropathology likely includes alpha-synucleinopathy in the olfactory bulb at an earlier stage (Braak's stagel) than pathology in the substantia nigra, which is not observed until stage 3. In this report, we investigated the distribution and cell types affected by alpha-synuclein in the olfactory bulb of transgenic mice (2-8 months of age) expressing the human A53T variant of alpha-synuclein. alpha-Synuclein immunostaining progressively affects interneurons and mitral cells. Double labeling studies demonstrate that dopaminergic cells are hardly involved, whereas glutamatergic- and calcium binding protein-positive cells are severely affected. This temporal evolution and the cell types expressing a-synuclein are reminiscent of idiopathic Parkinson's disease and support the usefulness of this model to address specific topics in the premotor phase of the disease. (C) 2010 Movement Disorder Society
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