Journal
MOVEMENT DISORDERS
Volume 25, Issue 16, Pages 2777-2784Publisher
WILEY
DOI: 10.1002/mds.23407
Keywords
positron emission tomography; basal ganglia; neuroplasticity; treadmill exercise
Categories
Funding
- USC CTSI
- Parkinson's Disease Foundation, Team Parkinson (Los Angeles)
- Parkinson Alliance
- Whittier Parkinson's Disease Education Group
- NINDS [RO1 NS44327-1]
- NIA [AG 21937]
- U.S. Army NETRP [W81XWH-04-1-0444]
- USC
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The purpose of the current study was to examine changes in dopamine D2 receptor (DA-D2R) expression within the basal ganglia of MPTP mice subjected to intensive treadmill exercise. Using Western immunoblotting analysis of synaptoneurosomes and in vivo positron emission tomography (PET) imaging employing the DA-D2R specific ligand [F-18]fallypride, we found that high intensity treadmill exercise led to an increase in striatal DA-D2R expression that was most pronounced in MPTP compared to saline treated mice. Exercise-induced changes in the DA-D2R in the dopamine-depleted basal ganglia are consistent with the potential role of this receptor in modulating medium spiny neurons (MSNs) function and behavioral recovery. Importantly, findings from this study support the rationale for using PET imaging with [F-18] fallypride to examine DA-D2R changes in individuals with Parkinson's Disease (PD) undergoing high-intensity treadmill training. (C) 2010 Movement Disorder Society
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