Journal
MOVEMENT DISORDERS
Volume 25, Issue 3, Pages 300-308Publisher
WILEY
DOI: 10.1002/mds.22982
Keywords
thalamus; local field potentials; Tourette syndrome; deep brain stimulation
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Funding
- Tourette Syndrome Association
- Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli, Regina Elena (Milan, Italy)
- University degli Studi di Milano (Italy)
- IRCCS Galeazzi (Milan, Italy)
- Ministero della Sanita (Italy)
- Ministero dell'Universita e della Ricerca Scientifica (Italy)
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Deep brain stimulation (DBS) of the ventralis oralis (VO) complex of the thalamus improves tics in patients with Tourette syndrome (TS). To neurophysiologically describe the VO complex we recorded, in seven patients with TS undergoing DBS electrode implantation, single-unit activity during surgery and local field potentials (LFPs) a few days after Surgery. Single unit recordings showed that the VO complex is characterized by a localized pattern of bursting neuronal activity. LFP spectra demonstrated that VO of TS patients has a prominent oscillatory activity at low frequencies (2-7 Hz) and in the a-band (8-13 Hz), and a virtually absent beta activity. In each patient, the main LFP frequency significantly correlated with single-unit interburst frequency. In conclusion, we observed an oscillatory bursting activity in the VO as target region in patients with severe TS Undergoing DBS surgery. (C) 2010 Movement Disorder Society
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