Journal
MOVEMENT DISORDERS
Volume 24, Issue 11, Pages 1561-1570Publisher
WILEY
DOI: 10.1002/mds.22505
Keywords
Parkinson's disease; impulse control disorders; dopamine dysregulation syndrome; punding, mesolimbic; reward; ventral striatum
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Antiparkinson therapy can be the primary cause of it range of nonmotor symptoms that include it set of complex disinhibitory psychomotor pathologies and are linked by their repetitive. reward or incentive-based natures. These behaviors relate to aberrant or excessive dopamine receptor stimulation and encompass impulse control disorders (ICDs), punding, and the dopamine clysregulation syndrome (DIDS). Common ICDs include pathological gambling, hypersexuality, compulsive eating, Bind Compulsive buying. This review focuses on the phenomenology, epidemiology, and methods to identify and rate these disorders. The management of dopaminergic drug-related Compulsive behaviors is discussed in the light of the current understanding of the neurobiological substrate of these disorders. (C) 2009 Movement Disorder Society
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