Journal
MOVEMENT DISORDERS
Volume 24, Issue 10, Pages 1519-1523Publisher
WILEY-LISS
DOI: 10.1002/mds.22481
Keywords
alpha-synuclein; monkeys; MPTP; parkinsonism; substantia nigra
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The recent knowledge that 10 years after transplantation surviving human fetal neurons adopt the histopathology of Parkinson's disease suggests that Lewy body formation takes a decade to achieve. To determine whether similar histopathology occurs in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-primate models over a similar timeframe, the brains of two adult monkeys made parkinsonian in their youth with intermittent injections of MPTP were studied. Despite substantial nigral degeneration and increased alpha-synuclein immunoreactivity within surviving neurons, there was no evidence of Lewy body formation. This suggests that MPTP-induced oxidative stress and inflammation per se are not sufficient for Lewy body formation, or Lewy bodies are human specific. (C) 2009 Movement Disorder Society
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