Journal
MOVEMENT DISORDERS
Volume 24, Issue 10, Pages 1504-1511Publisher
WILEY
DOI: 10.1002/mds.22662
Keywords
Parkinson's disease; PET; dementia
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Funding
- AKF program of the University of Tuebingen
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In Parkinson's disease patients with cognitive deterioration, regional cortical hypometabolism has been observed with [F-18]fluorodeoxyglucose-positron emission tomography (FDG-PET). Our aim was to develop a robust method to subsume the overall degree of metabolic deterioration in Parkinson's disease by means of a single index and to investigate which of the clinical features correlates best with hypometabolism. Twenty-two Parkinson's patients (10 demented) and seven controls underwent FDG-PET. A metabolic index (mean relative uptake in typically affected regions) was calculated for each patient and compared with scores for cognition [Minimental State Examination (MMSE)], motor performance [Unified Parkinson's Disease Rating Scale (UPDRS III)] and behavior (Neuropsychiatric Inventory). In stepwise linear regression analysis, MMSE (P < 0.001) score showed the only significant effect. Estimated sensitivity and specificity for DSM-IV diagnosis of dementia were high for the metabolic index (MI), with 91 and 100%. Taken together, the presented data indicate that cerebral hypometabolism in Parkinson's disease is primarily associated with cognitive impairment. (C) 2009 Movement Disorder Society
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