Journal
MOVEMENT DISORDERS
Volume 23, Issue -, Pages S497-S508Publisher
WILEY
DOI: 10.1002/mds.22028
Keywords
levodopa; history
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The discoveries of dopamine as a neurotransmitter in the brain. its depletion in patients with Parkinson disease., and its replacement with levodopa therapy were major revolutionary events in the rise to effective therapy for patients with this disorder. This review describes these events and the persons who carried out these accomplishments. Their impact went beyond a single clinical entity of parkinsonism, for it opened LIP the beginning of a Much better understanding of the role of dopamine in other neurologic movement disorders and also in many Psychiatric diseases. (c) 2008 Movement Disorder Society.
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