Journal
MOVEMENT DISORDERS
Volume 23, Issue 1, Pages 114-118Publisher
WILEY-LISS
DOI: 10.1002/mds.21760
Keywords
bilateral striatal necrosis; mitochondrial DNA; dystonia; deep brain stimulation
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Bilateral striatal necrosis (BSN) is relatively rare and has been related to a wide array of causes, including nuclear and mitochondrial DNA mutations. We report the clinical vignette of a patient with a 37 years-history of generalized dystonia secondary to BSN associated with multiple mitochondrial DNA deletions of undefined origin. Globus pallidus interna deep brain stimulation produced sustained benefit, with predominant improvements in disability. (c) 2007 Movement Disorder Society.
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