Journal
MOVEMENT DISORDERS
Volume 23, Issue 4, Pages 613-616Publisher
WILEY-LISS
DOI: 10.1002/mds.21919
Keywords
perceived imbalance; Parkinson's disease; prospective study
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Funding
- Intramural NIH HHS [Z01 ES101986-02] Funding Source: Medline
- NINDS NIH HHS [R01 NS048517, R01 NS048517-01A2] Funding Source: Medline
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We prospectively examined associations between perceived imbalance and Parkinson's disease (PD) risk in the Health Professional Follow-up Study (HPFS), and Nurses' Health Study (NHS). We included 39,087 men and 82,299 women free of PD at baseline (1990) in the current analyses. We documented 449 incident PD cases during 12 years followup. Subjects who reported difficulty with balance before 1990 (baseline) were 1.8 more times likely to develop PD, relative to those who reported no balance difficulty (pooled multivariate RR = 1.8; 95% CI: 1.3, 2.5; P < 0.0001). When we further examined associations between perceived imbalance at baseline and PD onset during different time periods, we found a significant elevation of PD risk only during the first 4 years of follow-up. This result suggests that the imbalance may in some cases be an early sign of PD, and may represent the onset of motor symptoms although they have not been clinically recognized. (C) 2008 Movement Disorder Society.
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