Journal
MOVEMENT DISORDERS
Volume 23, Issue 4, Pages 596-599Publisher
WILEY
DOI: 10.1002/mds.21908
Keywords
Parkinson's disease; rapid-eye-movement sleep behavior disorder; transcranial sonography; substantia nigra hyperechogenicity
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Idiopathic rapid-eye-movement (REM) sleep behavior disorder (iRBD) has been suggested to be a risk factor for subsequent development of neurodegenerative disorders, especially Parkinson's disease (PD) and other (alpha-synucleinopathies. At present, it is not possible to predict whether or not an iRBD patient will eventually develop PD. Here, we report 5 iRBD patients who underwent a test battery comprising a neurological examination (including UPDRS rating), mini mental state examination testing, transcranial sonography, olfactory function testing, and presynaptic dopamine transporter imaging with FP-CIT-SPECT. Our preliminary data show the diverse pattern of individual combinations of pathological findings when a multimodal assessment approach is applied in this patient group. Large-size longitudinal studies in iRBD patients are required to evaluate the usefulness of diagnostic tests to identify the subgroup of iRBD patients that is prone to develop PD. (C) 2008 Movement Disorder Society.
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