Journal
SEMINARS IN IMMUNOPATHOLOGY
Volume 38, Issue 1, Pages 11-27Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00281-015-0539-8
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Funding
- MRC [MR/L001543/1] Funding Source: UKRI
- Medical Research Council [MR/L001543/1] Funding Source: Medline
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Over recent years, significant progress has been made in characterisation of the underlying pathogenic mechanisms in psoriasis, a common cutaneous disease that is associated with major systemic co-morbidity and reduced life expectancy. Basic science discoveries have informed the design of novel therapeutic approaches, many of which are now under evaluation in late-stage clinical trials. Here we describe the complex interplay between immune cell types and cytokine networks that acts within self-perpetuating feedback loops to drive cutaneous inflammation in psoriasis. Genetic studies have been pivotal in the construction of the disease model and more recently have uncovered a distinct aetiology for rare, pustular variants of psoriasis. The translation of mechanistic insights into potential advancements in clinical care will also be described, including several treatments that target the interleukin-23 (IL-23)/T17 immune axis.
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