Journal
SEMINARS IN IMMUNOLOGY
Volume 27, Issue 5, Pages 310-314Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2015.10.002
Keywords
Aryl hydrocarbon receptor; IL-22; Mucosal tissues; Innate lymphoid cells
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Funding
- Crohn's & Colitis Foundation of America [274415]
- National Institutes of Health [1U01AI095542, R01DE021255, R21CA16719, RO1 CA176695]
- National Multiple Sclerosis Society [RG4687A1]
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Mucosal and barrier tissues are unique in that they mediate crosstalk between the host and the surrounding environment, which contains many potentially harmful factors. Therefore, it is critical that cell types present at barrier and mucosal surfaces are equipped with mechanisms to sense changes in the environment and to calibrate their responses accordingly. Aryl Hydrocarbon Receptor (AHR) is a ligand dependent transcription factor well known to generate biological responses to environmental pollutants, such as benzolalpyrene and halogenated dioxins. Surprisingly, in the last few years a large body of evidence has shown that AHR is also involved in maintaining homeostasis or in triggering pathology by modulating the biological responses of critical cell types at the barrier and mucosal interfaces. Here, we will review progresses in this field and discuss how targeting AHR activation may impact disease. (C) 2015 Elsevier Ltd. All rights reserved.
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