Journal
SEMINARS IN IMMUNOLOGY
Volume 27, Issue 6, Pages 397-409Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.03.014
Keywords
Monocyte; Bacterium; Fungus; Parasite; Innate immunity; Inflammation
Categories
Funding
- NIH [R01 093808, R21 105617, R01 103338, R21 095835, AI 093811, AI 094166, DK 103788, P30 CA008748]
- Burroughs Wellcome Fund Investigator in the Pathogenesis of Infectious Diseases Award
- Hirschl Caulier Award
- Broad Medical Research Program
- Kevin and Marsha Keating Family Foundation
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Circulating blood monocytes are a heterogeneous leukocyte population that contributes critical antimicrobial and regulatory functions during systemic and tissue-specific infections. These include patrolling vascular tissue for evidence of microbial invasion, infiltrating peripheral tissues and directly killing microbial invaders, conditioning the inflammatory milieu at sites of microbial tissue invasion, and orchestrating the activation of innate and adaptive immune effector cells. The central focus of this review is the in vivo mechanisms by which monocytes and their derivative cells promote microbial clearance and immune regulation. We include an overview of murine models to examine monocyte functions during microbial challenges and review our understanding of the functional roles of monocytes and their derivative cells in host defense against bacteria, fungi, and parasites. (C) 2016 Elsevier Ltd. All rights reserved.
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