Journal
SEMINARS IN IMMUNOLOGY
Volume 27, Issue 6, Pages 369-378Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.smim.2016.03.017
Keywords
Macrophage; Erythro-myeloid progenitor; Tissue specification; Pulse labeling models; Mononuclear phagocytes
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Funding
- DFG (German Research Foundation)
- BMBF
- Sobek Foundation
- DFG [SFB 992, FOR1336, PR 577/8-1]
- Fritz-Thyssen Foundation
- Gemeinnutzige Hertie Foundation (GHST)
- Institut Pasteur
- Agence Nationale de la Recherche (Laboratoire d'Excellence Revive, Investissement d'Avenir) [ANR-10-LABX-73]
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Macrophages are important for tissue development, homeostasis as well as immune response upon injury or infection. For a long time they were only seen as one uniform group of phagocytes with a common origin and similar functions. However, this view has been challenged in the last decade and revealed a complex diversity of tissue resident macrophages. Here, we want to present the current view on macrophage development and tissue specification and we will discuss differences as well as common patterns between heterogeneous macrophage subpopulations. (C) 2016 Elsevier Ltd. All rights reserved.
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