Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 20, Issue 1, Pages 42-46Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2014.12.006
Keywords
Bilirubin; Kernicterus; Auditory neuropathy; Hyperbilirubinemia; Auditory brainstem response
Categories
Funding
- NIH [R01 DC010075, R56 DC010164]
- HHMI
- Stanford Medical Scholars Research Program grant
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Hyperbilirubinemia occurs commonly in neonates and is usually mild and transient, with no long-lasting sequelae. However, bilirubin-induced neurologic damage may occur in some infants. The auditory pathway is the most sensitive part of the central nervous system to bilirubin-induced toxicity, and permanent sequelae may result from only moderately elevated total serum/plasma bilirubin levels. The damage to the auditory system occurs primarily within the brainstem and cranial nerve VIII, and manifests clinically as auditory neuropathy spectrum disorder. (C) 2014 Elsevier Ltd. All rights reserved.
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