Journal
SEMINARS IN FETAL & NEONATAL MEDICINE
Volume 20, Issue 1, Pages 52-57Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.siny.2014.12.003
Keywords
Hyperbilirubinemia; Neonate; Outcomes; Cognition; Developmental disabilities
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Funding
- Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, under the Mentored Patient-oriented Research Career Development Award [K23HD071971]
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Bilirubin-induced neurologic dysfunction (BIND) is the constellation of neurologic sequelae following milder degrees of neonatal hyperbilirubinemia than are associated with kernicterus. Clinically, BIND may manifest after the neonatal period as developmental delay, cognitive impairment, disordered executive function, and behavioral and psychiatric disorders. However, there is controversy regarding the relative contribution of neonatal hyperbilirubinemia versus other risk factors to the development of later neurodevelopmental disorders in children with BIND. In this review, we focus on the empiric data from the past 25 years regarding neurodevelopmental outcomes and BIND, including specific effects on developmental delay, cognition, speech and language development, executive function, and the neurobehavioral disorders, such as attention deficit/hyperactivity disorder and autism. (C) 2014 Elsevier Ltd. All rights reserved.
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