Journal
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
Volume 39, Issue -, Pages 43-55Publisher
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2015.02.013
Keywords
Cancer; Autophagy; Pro tumor; Anti-tumor; Apoptosis; Therapy
Categories
Funding
- Rapid Grant for Young Investigators (RGYI), India [BT/PR1/5090/GBD/27/309/2011]
- Department of Biotechnology
- Science and Engineering Research Board (SERB), India [SR/SO/BB-0101/2012]
- Council of Scientific and Industrial Research (CSIR) [37(1608)/13/EMR-II]
- Human Resource Development Group, Government of India
Ask authors/readers for more resources
Autophagy in cancer is an intensely debated concept in the field of translational research. The dual nature of autophagy implies that it can potentially modulate the pro-survival and pro-death mechanisms in tumor initiation and progression. There is a prospective molecular relationship between defective autophagy and tumorigenesis that involves the accumulation of damaged mitochondria and protein aggregates, which leads to the production of reactive oxygen species (ROS) and ultimately causes DNA damage that can lead to genomic instability. Moreover, autophagy regulates necrosis and is followed by inflammation, which limits tumor metastasis. On the other hand, autophagy provides a survival advantage to detached, dormant metastatic cells through nutrient fueling by tumor-associated stromal cells. Manipulating autophagy for induction of cell death, inhibition of protective autophagy at tissue-and context-dependent for apoptosis modulation has therapeutic implications. This review presents a comprehensive overview of the present state of knowledge regarding autophagy as a new approach to treat cancer. (C) 2015 Elsevier Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available